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Literature summary extracted from

  • Doisaki, M.; Katano, Y.; Nakano, I.; Hirooka, Y.; Itoh, A.; Ishigami, M.; Hayashi, K.; Goto, H.; Fujita, Y.; Kadota, Y.; Kitaura, Y.; Bajotto, G.; Kazama, S.; Tamura, T.; Tamura, N.; Feng, G.G.; Ishikawa, N.; Shimomura, Y.
    Regulation of hepatic branched-chain alpha-keto acid dehydrogenase kinase in a rat model for type 2 diabetes mellitus at different stages of the disease (2010), Biochem. Biophys. Res. Commun., 393, 303-307.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.4 BDK quantitative real-time PCR expression analysis Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.4 ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] Rattus norvegicus inactivation by phosphorylation of BCKDH ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.4 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.4 hepatocyte
-
 Rattus norvegicus
-
2.7.11.4 liver activity of BDK is higher in fatty diabetic rats than in lean non-diabetic rats Rattus norvegicus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.4 ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] inactivation by phosphorylation of BCKDH Rattus norvegicus ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.4 BCKDH kinase
-
 Rattus norvegicus
2.7.11.4 BDK
-
 Rattus norvegicus
2.7.11.4 branched-chain alpha-keto acid dehydrogenase kinase
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.4 ATP
-
 Rattus norvegicus

Expression

EC Number Organism Comment Expression
2.7.11.4 Rattus norvegicus insulin is known to increase the enzyme expression in cultured rat hepatocytes up

General Information

EC Number General Information Comment Organism
2.7.11.4 malfunction the BDK activity is decreased in the livers of streptozotocin-induced diabetic rats Rattus norvegicus
2.7.11.4 additional information activity of BDK practically corresponds with plasma insulin concentrations Rattus norvegicus
2.7.11.4 physiological function branched-chain alpha-keto acid dehydrogenase kinase is responsible for the regulation of branched-chain alpha-keto acid dehydrogenase complex, which is the rate-limiting enzyme in the catabolism of branched-chain amino acids Rattus norvegicus